{"id":11092,"date":"2010-10-31T13:07:06","date_gmt":"2010-10-31T12:07:06","guid":{"rendered":"http:\/\/mono-1en-1823"},"modified":"2010-10-31T13:07:06","modified_gmt":"2010-10-31T12:07:06","slug":"is-genomes-shape-as-important-as-its-content","status":"publish","type":"post","link":"https:\/\/monochrom.at\/blog\/2010\/10\/31\/is-genomes-shape-as-important-as-its-content\/","title":{"rendered":"Is Genome&#8217;s Shape as Important as Its Content?"},"content":{"rendered":"<blockquote><p>\n\tIf there is one thing that recent advances in genomics<br \/>\n\thave revealed, it is that our genes are interrelated, &#8220;chattering&#8221; to<br \/>\n\teach other across separate chromosomes and vast stretches of DNA.<br \/>\n\tAccording to researchers at The Wistar Institute, many of these complex<br \/>\n\tassociations may be explained in part by the three-dimensional structure<br \/>\n\tof the entire genome.<\/p>\n<p>\tA given cell&#8217;s DNA spends most of its active lifetime in a tangled<br \/>\n\tclump of chromosomes, which positions groups of related genes near to<br \/>\n\teach other and exposes them to the cell&#8217;s gene-controlling machinery.<br \/>\n\tThis structure, the researchers say, is not merely the shape of the<br \/>\n\tgenome, but also a key to how it works.<\/p>\n<p>\tTheir study, published online as a featured article in the journal <em>Nucleic Acids Research<\/em>,<br \/>\n\tis the first to combine microscopy with advanced genomic sequencing<br \/>\n\ttechniques, enabling researchers to literally see gene interactions. It<br \/>\n\tis also the first to determine the three-dimensional structure of the<br \/>\n\tfission yeast genome, <em>S. pombe. <\/em>Applying this technique to the<br \/>\n\thuman genome may provide both scientists and physicians a whole new<br \/>\n\tframework from which to better understand genes and disease, the<br \/>\n\tresearchers say.\n<\/p><\/blockquote>\n<p><a href=\"http:\/\/www.wistar.org\/news_info\/pressreleases\/pr_10.29.10.htm\">Link<br \/>\n<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If there is one thing that recent advances in genomics have revealed, it is that our genes are interrelated, &#8220;chattering&#8221; to each other across separate chromosomes and vast stretches of DNA. According to researchers at The Wistar Institute, many of these complex associations may be explained in part by the three-dimensional structure of the entire &#8230; <a title=\"Is Genome&#8217;s Shape as Important as Its Content?\" class=\"read-more\" href=\"https:\/\/monochrom.at\/blog\/2010\/10\/31\/is-genomes-shape-as-important-as-its-content\/\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"koromo_page_header":"","footnotes":""},"categories":[4],"tags":[],"class_list":["post-11092","post","type-post","status-publish","format-standard","hentry","category-english-blog","koromo-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50"],"_links":{"self":[{"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/post\/11092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/post"}],"about":[{"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/comments?post=11092"}],"version-history":[{"count":0,"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/post\/11092\/revisions"}],"wp:attachment":[{"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/media?parent=11092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/categories?post=11092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/monochrom.at\/blog\/wp-json\/wp\/v2\/tags?post=11092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}